Epidermodysplasia verruciformis

Common card · No. 203513

Epidermodysplasia verruciformis (EV) is a skin condition characterised by warty skin lesions. It results from an abnormal susceptibility to HPV infection (HPV). It is associated with a high lifetime risk of squamous cell carcinomas in skin. It generally presents with scaly spots and small bumps particularly on the hands, feet, face, and neck; typically beginning in childhood or a young adult. The bumps tend to be flat, grow in number, and then merge to form plaques. On the trunk, it typically appears like pityriasis versicolor; lesions are slightly scaly and tan, brown, red, or pale. On the elbows, it may appear like psoriasis. On the forehead, neck, and trunk, the lesions may appear like seborrheic keratosis. It is most frequently inherited as an autosomal recessive trait, with some reports of autosomal dominant and X-linked inheritance. Other types include atypical EV which develops due to gene mutations that cause an impaired immune system, and acquired EV which occurs due to acquired...

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