Shope papilloma virus
Papilloma virus which infects certain leporids
Shope papilloma virus
The Shope papilloma virus (SPV), also known as cottontail rabbit papilloma virus (CRPV) or Kappapapillomavirus 2, is a papillomavirus which infects certain species of rabbit and hare, causing cancerous lesions (carcinomas) resembling horns, typically on or near the animal's head. The carcinomas can metastasize or become large enough to interfere with the host's ability to eat, causing starvation. Richard E. Shope investigated the horns and discovered the virus in 1933, an important breakthrough in the study of oncoviruses. The virus was originally discovered in cottontail rabbits in the Midwestern United States but can also infect brush rabbits, black-tailed jackrabbits, snowshoe hares, European rabbits, and domestic rabbits.
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