Thiazide

Common card · No. 463358

Thiazides () are a class of diuretics based on the chemical structure of benzothiadiazine. Thiazides are used in the treatment of hypertension. The first approved drug of this class was chlorothiazide in 1958. Thiazide-like diuretics, such as indapamide, are sometimes called thiazides because they act on the same receptor, but do not have the thiazide chemical structure. The thiazide receptor is a sodium-chloride transporter that pulls NaCl from the lumen in the distal convoluted tubule of the kidneys. Thiazide diuretics inhibit this receptor, causing the body to release NaCl and water into the urine, thereby increasing the amount of urine produced each day.

Read on Wikipedia · Image Fvasconcellos 20:39, 21 November 2007 (UTC), Public domain