Hereditary nonpolyposis colorectal cancer

Uncommon card · No. 134666

Hereditary nonpolyposis colorectal cancer (HNPCC) is a hereditary predisposition to colon cancer. HNPCC (Lynch syndrome but see §Terminology below), an autosomal dominant genetic condition that is most commonly associated with a high risk of colon cancer and secondarily most associated with endometrial cancer, as well as ovarian, stomach, small intestine, hepatobiliary tract, upper urinary tract, brain, and skin cancers. The increased risk for these cancers is due to inherited genetic mutations that impair DNA mismatch repair. It is a type of cancer syndrome. Other HNPCC conditions include Lynch-like syndrome, polymerase proofreading-associated polyposis, and familial colorectal cancer type X.

Read on Wikipedia · Image Nephron, CC BY-SA 3.0