Coffin–Siris syndrome
Medical condition
Coffin–Siris syndrome
Coffin–Siris syndrome (CSS), first described in 1970 by Dr Grange S. Coffin and Dr E. Siris, is a rare genetic disorder that causes developmental delays and absent fifth finger and toe nails. There had been 31 reported cases by 1991. The number of occurrences since then has grown and is now reported to be around 250-550 individuals . The differential includes Nicolaides–Baraitser syndrome.
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