Lactate dehydrogenase

Common card · No. 241757

Lactate dehydrogenase (LDH or LD) is a type of enzyme found in nearly all living cells which catalyzes the conversion of pyruvate to lactate and back (as it converts the cofactor NAD+ to NADH and back). LDH exists in four distinct enzyme classes. This article is specifically about the NAD(P)-dependent L-lactate dehydrogenase (EC 1.1.1.27), which is the type that has been found in humans. The other types act on the right-handed version of lactate (D-lactate dehydrogenase), or use different cofactors (L-lactate dehydrogenase (cytochrome) and D-lactate dehydrogenase (cytochrome)). LDH is expressed extensively in body tissues, such as blood cells and heart muscle. Because it is released during tissue damage, it is a marker of common injuries and disease such as heart failure.

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