Advanced glycation end-product

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Advanced glycation end-products (AGEs) are proteins or lipids that become glycated after exposure to sugars. They are formed through a series of non-enzymatic reactions explained in further detail below, and their accumulation is associated with a variety of metabolic diseases such as diabetes, atherosclerosis, chronic kidney disease, age-related macular degeneration (even in non-diabetic animals), and Alzheimer's disease. They are sometimes inaccurately referred to as glycosylation end-products, but that term refers exclusively to the process of enzymatically attaching sugars to other macromolecules through glycosidic linkages, rather than glycation which is stochastic and by definition pathological.

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