Paraneoplastic pemphigus

Common card · No. 424402

Paraneoplastic pemphigus (PNP) is an autoimmune disorder stemming from an underlying tumor. It is hypothesized that antigens associated with the tumor trigger an immune response resulting in blistering of the skin and mucous membranes. While patients with malignant tumors and benign tumors are both at risk, those with malignant tumors experience a very high mortality rates (their death rate is about 90%). Current treatment focuses on palliative care, wound healing, and administration of immunosuppressant corticosteroids; this treatment has not demonstrated a high success rate. Research currently focuses on treating the underlying tumor, in order to alleviate the symptoms of PNP.

Read on Wikipedia