Lissencephaly
Birth defect in which the brain lacks surface folds
Lissencephaly
Lissencephaly (, meaning 'smooth brain') is a set of rare brain disorders whereby the whole or parts of the surface of the brain are smooth. It is caused by defective neuronal migration during the 12th to 24th weeks of gestation, resulting in a lack of development of brain folds (gyri) and grooves (sulci). It is a form of cephalic disorder. Terms such as agyria (no gyri) and pachygyria (broad gyri) are used to describe the appearance of the surface of the brain. Children with lissencephaly generally have significant developmental delays, but these vary greatly from child to child depending on the degree of brain malformation and seizure control. Life expectancy can be shortened, generally due to respiratory problems.
Read on Wikipedia · Image Brain-disease-gyrification.png: Lefèvre J, Mangin J-F (2010) A Reaction-Diffusion Model of Human Brain Development. PLoS Comput Biol 6(4): e1000749. doi:10.1371/journal.pcbi.1000749 (cropped by Danie…, CC BY 2.5
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