Α-Amanitin

Common card · No. 233506

α-Amanitin (alpha-Amanitin) is a cyclic peptide of eight amino acids. It is possibly the most deadly of all the amatoxins, toxins found in several species of the mushroom genus Amanita, one being the death cap (Amanita phalloides) as well as the destroying angel, a complex of similar species, principally A. virosa and A. bisporigera. It is also found in the mushrooms Galerina marginata, Lepiota subincarnata and Conocybe rugosa. The oral LD50 of amanitin is 100 μg/kg for rats. Amatoxins are part of the RiPP class of natural products. The fungal genes encoding the proprotein for α-amanitin belong to the same MSDIN protein family as those that encode for the phallotoxins.

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