Jones oxidation

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The Jones oxidation is an organic reaction for the oxidation of primary and secondary alcohols to carboxylic acids and ketones, respectively. It uses chromium trioxide in an acetonic acidic medium. It is named after its discoverer, Sir Ewart Jones. The reaction was an early method for the oxidation of alcohols. Its use in organic chemistry has been displaced by related reagents such as the pyridine complex of chromium trioxide ("Collins reagent"). Jones reagent is a solution prepared by dissolving chromium trioxide in aqueous sulfuric acid. To effect a Jones oxidation, this acidic mixture is then added to an acetone solution of the substrate. Alternatively, potassium dichromate can be used in place of chromium trioxide. The oxidation is very rapid and quite exothermic. Yields are typically high. The reagent is convenient and cheap. However, Cr(VI) compounds are carcinogenic, which deters the use of this methodology.

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