Metaxalone

Common card · No. 413275

Metaxalone, sold under the brand name Skelaxin, is a muscle relaxant medication used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions. It is a moderately strong muscle relaxant, with relatively low incidence of side effects. Its exact mechanism of action is not known, but it may be due to general central nervous system depression. Studies in vitro have shown metaxalone to suppress production of pro-inflammatory cytokines such as TNF-α and IL-6 and increase production of the antiinflammatory cytokine IL-13, however it also inhibits MAO-A and this may both contribute to its therapeutic effects and also is linked to toxicity in overdose. Common side effects include nausea, vomiting, drowsiness, and central nervous system (CNS) side effects, such as dizziness, headache, and irritability. The metabolism of metaxalone involves enzymes CYP1A2 and CYP2C19 in the cytochrome P450 system. Because many medications are metabolized by enzymes in this...

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