Common
Non-linear effects in enantioselective synthesis
In enantioselective synthesis, a non-linear effect refers to a process in which the enantiopurity of the catalyst (or the chiral auxiliary) does not correlate linearly with the enantiopurity of the product produced. This deviation from linearity is described as the non-linear effect, NLE. The linearity can be expressed mathematically, as shown in Equation 1. Stereoselection (i.e. the eeproduct) that is higher or lower than the enantiomeric excess of the catalyst (eecatalyst, relative to the equation) is considered non-routine behavior. e e product = e e max e e catalyst {\displaystyle ee_{\text{product}}=ee_{\max }ee_{\text{catalyst}}} For an ideal asymmetric reaction, the eeproduct may be described as the product of eemax multiplied by...
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