Amdiglurax
BDNF-modulating drug for depression and PTSD
Amdiglurax
Amdiglurax (INNTooltip International Nonproprietary Name), also known by its former developmental code names ALTO-100 and NSI-189 (short for "NeuralStem Inc. 189"), is a drug described as a hippocampal neurogenesis stimulant and indirect brain-derived neurotrophic factor (BDNF) modulator which is under development for the treatment of major depressive disorder (MDD), bipolar depression, and post-traumatic stress disorder (PTSD). There has also been interest in amdiglurax for possible treatment of cognitive impairment and neurodegeneration. It is taken orally. Amdiglurax's exact mechanism of action is unknown. However, it has been disclosed to act as a highly potent agonist of the TLX. On the other hand, its developer disclosed amdiglurax to act as a dual agonist and positive allosteric modulator ("ago-PAM") of the metabotropic glutamate mGlu5 receptor and attributed its antidepressant-like effects to this action. The drug is thought to work through indirectly enhancing BDNF signaling and...
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