Ebola vaccine

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An Ebola vaccine is a vaccine used to prevent Ebola virus disease (Ebola). There are six known species of ebolavirus; four of them cause Ebola disease. As of May 2026, there is one licensed vaccine against the Zaire ebolavirus species, and none against the other species. The rVSV-ZEBOV vaccine was first approved in the European Union in November 2019 and subsequently approved in the United States. It had been used extensively in the Kivu Ebola epidemic under a compassionate use protocol. A second vaccine, Zabdeno/Mvabea, had been licensed by the European Union in July 2020, but was withdrawn by the manufacturer in May 2026. Several vaccine candidates displayed efficacy to protect nonhuman primates (usually macaques) against lethal infection. Candidate vaccines include replication-deficient adenovirus vectors, replication-competent vesicular stomatitis (VSV) and human parainfluenza (HPIV-3) vectors, and virus-like nanoparticle preparations.The Ebola vaccine is on the World Health Organization...

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