Influenza A virus

Uncommon card · No. 87677

Influenza A virus, or IAV, is a pathogen with strains that cause seasonal flu in humans; it can also infect birds and some mammals. Strains of IAV circulate constantly in bats, pigs, horses, and dogs, while other mammals may be infected occasionally. It has also been the cause of a number of pandemics, most notably the Spanish Flu pandemic from 1918–1920. Subtypes of IAV are defined by the combination of the molecules on the surface of the virus which provoke an immune response; for example, "H1N1" denotes a subtype that has a type-1 hemagglutinin (H) protein and a type-1 neuraminidase (N) protein. Variations within subtypes affect how easily the virus spreads, the severity of illness, and its ability to infect different hosts. The virus changes through mutation and genetic reassortment, allowing it to evade immunity and sometimes jump between species. Symptoms of human seasonal flu usually include fever, cough, sore throat, muscle aches, headache and, in severe cases, breathing problems...

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