Sliding filament theory

Common card · No. 289503

The sliding filament theory explains the mechanism of muscle contraction based on muscle proteins that slide past each other to generate movement. According to the sliding filament theory, the myosin (thick filaments) of muscle fibers slide past the actin (thin filaments) during muscle contraction, while the two groups of filaments remain at relatively constant length. The theory was independently introduced in 1954 by two research teams, one consisting of Andrew Huxley and Rolf Niedergerke from the University of Cambridge, and the other consisting of Hugh Huxley and Jean Hanson from the Massachusetts Institute of Technology. It was originally conceived by Hugh Huxley in 1953. Andrew Huxley and Niedergerke introduced it as a "very attractive" hypothesis. Before the 1950s, there were several competing theories on muscle contraction, including electrical attraction, protein folding, and protein modification. The novel theory directly introduced a new concept called cross-bridge theory (classically...

Read on Wikipedia · Image David Richfield (User:Slashme) When using this image in external works, it may be cited as follows: Richfield, David (2014). "Medical gallery of David Richfield". WikiJournal of Medicine 1 (2). DOI:1…, CC BY-SA 3.0