Williamson ether synthesis
Method for preparing ethers
Williamson ether synthesis
The Williamson ether synthesis is an organic reaction, forming an ether from an organohalide and a deprotonated alcohol (alkoxide). This reaction was developed by Alexander Williamson in 1850. Typically it involves the reaction of an alkoxide ion with a primary alkyl halide via an SN2 reaction. Versions of this reaction are also called O-alkylation. The general reaction mechanism is as follows:
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