Prurigo nodularis

Uncommon card · No. 189100

Prurigo nodularis (PN) is a chronic, inflammatory skin disease characterized by intense pruritus and symmetrically distributed, firm papules or nodules on the skin. The core pathogenesis of PN involves a three-stage model comprising primary epidermal barrier defect, type 2 immune inflammation, and neural structural remodeling. Clinically, the diagnosis of PN relies on the characteristic morphology of skin lesions, their distinctive anatomical distribution, and the pattern of chronic severe pruritus. Epidemiological data indicate that the global prevalence of PN is approximately 0.083%, predominantly affecting adults and the elderly, with higher incidence rates observed in females and individuals of Black ethnicity. Treatment of PN follows a multimodal, stepwise approach, ranging from topical corticosteroids and phototherapy to biologic agents targeting the type 2 inflammatory pathway. Because PN is frequently associated with systemic diseases (such as diabetes and renal disease), peripheral...

Read on Wikipedia · Image Michael Katotomichelakis, Dimitrios G Balatsouras, Konstantinos Bassioukas, Nikolaos Kontogiannis, Konstantinos Simopoulos, Vassilios Danielides., CC BY 2.0