Common
Kell antigen system
Human blood group classification
Kell antigen system
The Kell antigen system (also known as the Kell–Cellano system) is a human blood group system, that is, a group of antigens on the human red blood cell surface which are important determinants of blood type and are targets for autoimmune or alloimmune diseases which destroy red blood cells. The Kell antigens are K, k, Kpa, Kpb, Kpc, Jsa, Jsb, Wka, Cote and other variants. The Kell antigens are peptides found within the Kell blood group glycoprotein, a 93-kilodalton transmembrane zinc-dependent endopeptidase which is encoded by the gene KEL, and is responsible for cleaving endothelin-3.
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