
Kambo (drug)
Traditional South American practice involving frog secretions

Traditional South American practice involving frog secretions
Kambo, also known as sapo (from Portuguese: sapo, lit. 'toad') or vacina-do-sapo, is substance derived from the natural secretions of an amphibian belonging to the Phyllomedusa family. Commonly the dried skin secretions of the giant leaf frog, known as the kambô in Portuguese, a species of frog, are used for ritualistic purposes with a strong religious and spiritual components. Less commonly it is used as a transdermal medicine, however, evidence for its effectiveness is limited. Kambo is usually used in a group setting, called a kambo circle or kambo ceremony. Some of the effects on humans include tachycardia, hypotension, nausea, as well as vomiting and sometimes bowel movements owing to smooth-muscle contractions. A literature review of acute adverse events identified 11 reported cases involving severe adverse effects, including psychosis, SIADH, kidney injury, liver injury, dermatomyositis, esophageal rupture and seizures, with some cases resulting in death. Such severe outcomes are...
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