Parietal cell

Common card · No. 488110

Parietal cells (also known as oxyntic cells) are epithelial cells in the stomach that secrete hydrochloric acid (HCl) and intrinsic factor. These cells are located in the gastric glands found in the lining of the fundus and body regions of the stomach. They contain an extensive secretory network of canaliculi from which the HCl is secreted by active transport into the stomach. The gastric hydrogen potassium ATPase (H+/K+ ATPase) is highly enriched in parietal cells and transports H+ against a concentration gradient of about 3-4 million to 1 between plasma and the parietal cell canaliculus, generating one of the steepest ion gradients in mammalian tissues. Parietal cells are primarily regulated via histamine, acetylcholine and gastrin signalling from both central and local modulators.

Read on Wikipedia · Image Mikael Häggström, M.D. Author info - Reusing images - Conflicts of interest: None Mikael Häggström, M.D., CC0