Common
Capillary leak syndrome
Escape of blood plasma through capillary walls into surrounding tissues
Capillary leak syndrome
Capillary leak syndrome, or vascular leak syndrome, is characterized by the escape of blood plasma through capillary walls, from the blood circulatory system to surrounding tissues, muscle compartments, organs or body cavities. It is a phenomenon most commonly witnessed in sepsis, and less frequently in autoimmune diseases, differentiation syndrome, engraftment syndrome, hemophagocytic lymphohistiocytosis, the ovarian hyperstimulation syndrome, viral hemorrhagic fevers, and snakebite and ricin poisoning. Pharmaceuticals, including the chemotherapy medications gemcitabine and denileukin diftitox, as well as certain interleukins and monoclonal antibodies, can also cause capillary leaks. These conditions and factors are sources of secondary capillary leak syndrome, and it is often difficult to diagnose and treat because of its complex pathophysiology and the absence of standardized diagnostic criteria. Systemic capillary leak syndrome (SCLS), also called Clarkson's disease, or primary capillary...
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