Aging brain

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Aging brain refers to biological and functional changes that occur in the brain as individuals advance in age. It encompasses both the normal alterations which are universally experienced and abnormalities induced by illnesses, diagnosed or not. The concept is most often used in relation to humans. Since life extension is only pertinent if accompanied by healthspan extension, and, more importantly, by preserving brain health and cognition, finding rejuvenating approaches that act simultaneously in peripheral tissues and in brain function is a key strategy in the development of rejuvenation technology. Aging is a major risk factor for most common neurodegenerative diseases, including mild cognitive impairment, dementias including Alzheimer's disease, cerebrovascular disease, Parkinson's disease, and Amyotrophic Lateral Sclerosis. While much research has focused on diseases of aging, there are few informative studies on the molecular biology of the aging brain[1] in the absence of neurodegenerative...

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